Neurontin/Lyrica Block Formation of Synapses in Brain


As I know MANY spoonies who are on Neurontin or Lyrica, I wanted to put this out the second I saw it (see below). I took it myself on two separate occasions and felt within a short period both times that the drugs were doing more harm than good for myself, even though they dulled a great deal of the pain I was feeling at the time. If you’re on these drugs, I would consult with your physician right away. Personally, I myself stick with holistic medications which heal and generate new healthy tissue. It works. You should check it out.


January 8, 2017 by Posted in: Uncategorized

BY: Byron J. Richards, Board Certified Clinical Nutritionist

Neurontin and its newer more potent version, Lyrica, are widely used for off-label indications that are an outright flagrant danger to the public. These blockbuster drugs were approved for use even though the FDA had no idea what they actually did in the brain. A shocking new study shows that they block the formation of new brain synapses1, drastically reducing the potential for rejuvenating brain plasticity – meaning that these drugs will cause brain decline faster than any substance known to mankind.

The problem of these drugs is compounded by their flagrant illegal marketing. Neurontin was approved by the FDA for epilepsy back in 1994. The drug underwent massive illegal off-label promotion that cost Warner-Lambert 430 million dollars (the very first big fine for off-label promotion). The drug is now owned by Pfizer. Pfizer also owns Lyrica, a super-potent version of Neurontin. It has been approved by the FDA for various types of pain and fibromyalgia. Lyrica is one of four drugs which a subsidiary of Pfizer illegally marketed, resulting in a $2.3 billion settlement against Pfizer.

Even though the marketing of these drugs has been heavily fined, they continue to rack up billions in sales from the off-label uses. Doctors use them for all manner of nerve issues because they are good at suppressing symptoms. However, such uses can no longer be justified because the actual mechanism of the drugs is finally understood and they are creating a significant long-term reduction in nerve health.

The researchers in the above study try to downplay the serious nature of the drugs by saying “adult neurons don’t form many new synapses.” That is simply not true. The new science is showing that brain health during aging relies on the formation of new synapses. Even these researchers managed to question the common use of these medications in pregnant women. How is a fetus supposed to make new nerve cells when the mother is taking a drug that blocks them?

These are the kind of situations the FDA should be all over. As usual, the FDA is sitting around pondering a suicide warning for Lyrica while its off-label uses include bi-polar disorder and migraine headaches. The FDA is likely to twiddle its thumbs for the next decade on the brain damage issue. Consumer beware.

10 thoughts on “Neurontin/Lyrica Block Formation of Synapses in Brain

  1. I was on Lyrica for 18 months, almost 25 years ago for endometriosis (we didn’t know about the EDS yet) and it was hell. I wonder what my life is going to be like in the future because of this. I was so interested in just getting out of pain, even if temporary.

    Liked by 1 person

    1. I felt the same desperation when I went on it. I had yet to have my hysterectomy (I have endometriosis, too) and didnt know how to care for my joints yet (I also didnt yet know I had EDS or POTS) and tried a number of other drugs at the time that were just awful until I finally decided to start looking into what other people were doing and found alternatives. They were for FM and CFS, but they have similar symptoms. It has improved my quality of life a great deal. I by no means live a pain-free life and still struggle, as you can tell from my blogs, but at least I’m me, rather than the dumbed-down, drooling approximation of myself those drugs made me. I recommend lots of antioxidants to repair the effects and strengthen the neurological fibers and tissues of the body. Take a look at my post “What got me out out of bed” if you’re interested in learning more.


      1. I will definitely be reading that! We decided to not go the hysterectomy route, as it does not have a good outcome rate in women with disease placement as I have, mostly at the bowel, bladder, and pouch of Douglas. I do have a Mirena, that is quite good at suppressing what is Endo. For the longest time everything was blamed on endo. I could have broken my leg and it would have been, oh the old endo is acting up again! Now, I’m starting to see some of my abdominal pain is actually gastroenterology related. So we are having some territorial debate on that.

        Liked by 1 person

        1. With EDS, it produces so many varied symptoms and comorbid factors, you really have to push to be taken seriously. It’s so frustrating. I didn’t even know I had endo until I insisted they do the hysterectomy instead of an ablation. Then she saud it was one of the worst, weirdest things she’d ever seen. Go figure. The nuvaring helped me for a long time, though. If Mirena works, go for it. I just needed to be sure what was what because the GI issues were so bad. The hysterectomy helped, but not as much as I hoped. We sound like peas from the same pod!

          Liked by 1 person

          1. We do, indeed sound very similar! I only found out I had EDS two years ago (almost to the day!) After a nurse in the clinic noticed I was sitting oddly. I had been sitting with my legs crossed, feet to my pelvis, and my knees were touching the ground. Those flexible hips! I haven’t been enthusiastic to have a hysterectomy, partly because of the general dissatisfaction many women have felt, partly because I don’t think it will get better than Mirena and the meds I have, and partly because my grandmother had a hysterectomy and had terrible problems. Now, I know it’s not terribly logical, as surgery has come a long way since then, but she begged me to not have one, and I am hesitant. I’m currently 46, so 2 more Mirena and I should be done ☺. I’d like to avoid any surgery if I can.

            Liked by 1 person

            1. I was really against it, too. If I wasn’t bleeding months at a time and having such terrible PMDD, I wouldn’t have. I had laparoscopic surgery done with a DaVinci, though and the difference was amazing compared to others I’ve heard about. I also got to keep my ovaries, which makes a huge difference, but if you’re not far off from menopause and the Mirena works, do stick with it, because you’re right. No matter how far they’ve come, it’s still better to keep your uterus. There are complications I could still face down the road. I had it done at 44 and really wanted to wait, it just wasn’t possible anymore.

              Liked by 1 person

              1. I totally get that. There are choices we don’t want to make, but pain puts us in the position where our choices are limited sometimes. When my period returned after my first pregnancy, the first one hurt, the second one, I was in hospital and they were removing my appendix, certain it was about to rupture, but they couldn’t see it. When they operated, my appendix was fine, and didn’t my period arrive the next morning? I told my husband he must impregnate me immediately, as I had no other idea how to control the disease! I don’t know that I thought that through… but it worked out! I would have cut off my own head at that point, I think! ☺ Hugs!

                Liked by 1 person

                1. Yeah, I don’t miss those kinds of cramps anymore, that’s for sure! My diverticulitis was a close enough reminder. I hope you have a good week!

                  Liked by 1 person

  2. A thousand thanks for posting this. Some time ago, my UK GP prescribed this for chronic, long-term pain, but my instinct was not to get the Rx filled or take it. Years ago my instincts were the same regarding Vioxx, another pain medication I was prescribed also for pain.
    I have learned that UK doctors are prescribing gabapentin like doctors recommended tylenol in the ’70s. My own GP said it was a ‘miracle drug’ despite (after some pointed questions) finally admitting that he not know its mechanism of action. It’d be so wonderful to find a doctor that could simply be honest and put a patient’s well-being as priority.
    Your post will serve well those of us who choose to be informed, active participants in our own health care. Again, many thanks.

    Liked by 1 person

    1. Thank you, Sally. I know exactly what you mean about finding a doctor with better priorities. I fantasize that they are better in socialized systems with this than in our free enterprise American system, but I’ve heard similar complaints to yours out of the UK before. We patients must stick together, share our information and above all, advocate for ourselves in a way previous generations would never have considered. After so many years of this, I find it is me educating my doctors and not the other way around. You’re wise indeed to be an active participant in your own healthcare! Best of luck to you on finding the path to the best wellness you can acheive!


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