Parasym Plus is exactly what I needed at that moment. I noticed a difference in my fatigue levels on day one. On day 2, my inflammation dropped dramatically. I lost 7 pounds in the first 24 hours. It makes perfect sense. Ten extra pounds showed up on the scale when I arrived home from my 1200 mile trip, so I know exactly where that weight came from; it was inflammation caused by all those triggers. It only took 24 hours for my GI swelling to decrease, making it possible for my GI tract to begin functioning almost normally within just a few days.